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Science Behind the Therapy

Understanding the Science of V.A.C. Therapy

Proven therapy with more than 650 peer-reviewed articles, the clinical and economic benefits of V.A.C.® (Vacuum Assisted Closure®) Therapy, also known as NPWT (Negative Pressure Wound Therapy) are widely known. However, it is equally important to understand how V.A.C. Therapy works deep inside the wound to achieve these outcomes. The following sections describe how NPWT (Negative Pressure Wound Therapy), namely V.A.C. Therapy, promotes wound healing and how its unique mechanisms of action differentiate it from other NPWT devices.

 

What Makes Up the V.A.C. Therapy System

 

Three Critical Components, One Unique System

The V.A.C. Therapy System is comprised of three essential components that actively work together to help promote wound healing through granulation tissue formation.

Diagram

  1. V.A.C. Therapy Unit Provides intermittent and continuous therapy with integrated patient safety features
  2. SensaT.R.A.C.™ Technology Regulates pressure at the wound site to provide accurate delivery of prescribed therapy settings
  3. V.A.C. GranuFoam™ Dressings Help provide the necessary mechanisms to promote granulation tissue formation

 

How V.A.C. Therapy Promotes Granulation Tissue Formation

 

The Science Behind the System: Macrostrain and Microstrain

Under negative pressure, V.A.C. Therapy with proprietary V.A.C. GranuFoam Dressings applies mechanical forces to the wound to create an environment that promotes wound healing. These forces are known as macrostrain and microstrain.

Macrostrain

Macrostrain is the visible stretch that occurs when negative pressure contracts the foam.

Macrostrain:

Microstain

Microstrain is the microdeformation at the cellular level, which leads to cell stretch.1

Microstrain:

Using V.A.C. Therapy with V.A.C. GranuFoam Dressings results in both macrostrain and microstrain for advanced wound healing.

Watch a video of how V.A.C. Therapy works through macrostrain and microstrain.

 

Healing at a cellular level
 

 

How V.A.C. Therapy Removes Barriers to Healing

 

V.A.C. Therapy Mechanisms of Action

V.A.C. Therapy creates an environment that promotes wound healing through the following mechanisms:

Wound Healing Barrier V.A.C. Therapy Mechanism
Excess bacterial burden Removes infectious materials
Inadequate protection against infection Provides protected wound healing environment
Excess exudate Removes exudate
Excess edema (interstitial fluid) Reduces edema (interstitial fluid)
Absence of moisture Provides a moist wound healing environment
Lack of adequate blood flow Promotes perfusion
Lack of granulation tissue formation Removes barries to cell migration and proliferation

 

SensaT.R.A.C. Technology

V.A.C. Therapy uses SensaT.R.A.C.™ (Therapeutic Regulated Accurate Care) to:

 

Bibliography
Chen, C. M. (1997). Geometric control of cell life and death. Science , 276, 1425-1428.

Sui Huang, C. S. (1998). Control of Cyclin D1, p27Kip1, and Cell Cycle Progression in Human Capillary Endothelial Cells by Cell Shape and Cytoskeletal Tension . Molecular Biology of the Cell , 9 (11), 3179-319.

Joseph E, H. C. (2000). A prospective randomized trial of vacuum-assisted closure versus standard therapy of chronic non-healing wounds. Wounds , 12, 60-67.

Saxena, V. S., Hwang, C.-W. M., Huang, S. M., Eichbaum, Q. M., Ingber, D. M., & Orgill, D. P. (2004). Vacuum-Assisted Closure: Microdeformations of Wounds and Cell Proliferation. Plastic and Reconstructive Surgery: , 114 (5), 1086-1096.

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